Potassium hydroxy sulfite → HCID 53237382, compound

Participants

Reaction Steps

To a mixture of 4-(2-amino-pyrimidin-5-yl)-N1-tert-butyl-benzene-1,2-diamine (11 mg, 0.043 mmol) and 4-chloro-2-(3-methyl-1,2,4-oxadiazol-5-yl)-benzaldehyde (10 mg, 0.045 mmol) in DMF (5.0 mL) is added Oxone (27 mg, 0.044 mmol) in H2O (2.0 mL). The reaction mixture is stirred at room temperature for 1.5 hours and then quenched with saturated sodium thiosulfate aq. (25 mL). The quenched reaction mixture is extracted with EtOAc (25 mL×2) and the combined organic layers are washed with H2O (50 mL×2), dried with Na2SO4 and filtered. The filtrate is concentrated under reduced pressure and the residue is purified by silica gel flash column chromatography with 10% MeOH in CH2Cl2 as the eluent to afford the title compound (10 mg, 50%) as a white solid. LCMS (ESMS): m/z 460.20 (M++1)

Provenance & Evidence