HCID 58541889, compound → HCID 178464745, compound

Participants

Reaction Conditions

Reaction Steps

To a round bottom flask is added 2-(5-bromo-1-tert-butyl-1H-benzimidazol-2-yl)-benzamide (400 mg, 1.075 mmol) in N,N-dimethylformamide dimethyl acetal (5 mL). The reaction mixture is stirred at 110° C. for 5 hours. The reaction mixture is concentrated to remove all volatile material to afford 2-(5-bromo-1-tert-butyl-1H-benzimidazol-2-yl)-N-[1-dimethylamino-eth-(E)-ylidene]-benzamide (474 mg, 100%) ready for next step. LCMS (ESMS): m/z 441.71, 443.71 (M++1)

Provenance & Evidence