HCID 58541965, compound → HCID 58541933, compound

Participants

Reaction Steps

(5-{2-[5-(2-Amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-phenyl}-3-methyl-1,2,4-triazol-1-yl)-acetic acid ethyl ester (40 mg, 0.078 mmol) and Amberlyst A26 (OH− form) (450 mg, 0.6 mmol) are combined in acetonitrile (5 mL) and the mixture is agitated for 3 hours, filtered, and the isolate is washed with acetonitrile (2×5 mL). The product is purified by silica gel flash column chromatography eluting with 20% formic acid in acetonitrile (1 mL). The eluent is concentrated to afford the title compound (37 mg, 38%) LCMS (ESMS): m/z 483.2 (M++1)

Provenance & Evidence