Hydroxylamine → HCID 178448433, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-benzonitrile (1.1 mg, 2.99 mmol) in EtOH (20 mL) is added hydroxylamine 50% aqueous solution (3.94 mL 59.71 mmol) at room temperature. The solution is stirred at 80° C. for 2 hours. The reaction mixture is cooled to room temperature and the ethanol removed in vacuo. EtOAc (50 mL) is added and the organics washed with H2O then dried (Na2SO4), filtered and concentrated to afford 2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-N-hydroxy-benzamidine (1.1 g, 92%).

Provenance & Evidence