Methyl iodide → HCID 58542052, compound

Participants

Reaction Steps

To a vial is added 5-bromo-1-tert-butyl-2-[2-(5-methyl-1H-[1,2,4]triazol-3-yl)-phenyl]-1H-benzimidazole (73 mg, 0.178 mmol) in DMF (1.5 mL), followed by the addition of MeI (40 mg, 0.282 mmol) and K2CO3 (49 mg, 0.355 mmol). The reaction mixture is stirred at room temperature for 1 hour. The reaction mixture is diluted with EtOAc (20 mL), washed with water, brine, dried under anhydrous Na2SO4, filtered and concentrated. The residue is purified by silica gel flash column chromatography with 0-3% 7M NH3 in MeOH/CH2Cl2 as the eluent to afford 5-bromo-1-tert-butyl-2-[2-(1,5-dimethyl-1H-[1,2,4]triazol-3-yl)-phenyl]-1H-benzimidazole (44 mg, 58%) as an off-white solid. LCMS (ESMS): m/z 424.58, 426.51 (M++1).

Provenance & Evidence