HuagongsheHuagongshe Chemistry Print Report · For research reference only
Urea → 5-Fluoroisoindoline-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Urea | HCID 1176 | — |
| Reactant | 1,3-Isobenzofurandione, 5-fluoro- | HCID 67572 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-Fluoroisoindoline-1,3-dione | HCID 10899038 | 100.6% |
Reaction Steps
To 4-fluorophthalic anhydride (5.0 g, 30.10 mmol) in toluene (15 mL) is added urea (2.1 g). The reaction mixture is stirred at refluxed for 16 h. The reaction mixture is allowed to cool to room temperature, concentrated under reduced pressure and triturated with H2O (250 mL) to afford 5-fluoro-isoindole-1,3-dione (5.0 g, 100%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420655B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-4fbb8245889046fba2c7849229bb340b |
| Source note | uspto-grants-2013_04 |