HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 86660012, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | HCID 58541996 | HCID 58541996 | — |
| Product | HCID 86660012 | HCID 86660012 | — |
Reaction Steps
A solution of 5-fluoro-1,3-dioxo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (4.0 g, 15.08 mmol) in MeOH (20 mL) is refluxed for 1 hour. The reaction mixture is allowed to cool to room temperature and then concentrated under reduced pressure to afford 2-tert-butoxycarbonylaminocarbonyl-5-fluoro-benzoic acid methyl ester plus regioisomer (4.5 g, 100%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420655B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-c25c2c31c1ab4d0faf7330d2bdd3afc5 |
| Source note | uspto-grants-2013_04 |