反应详情

A solution of 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid (0.0088 mol) (example 4a) in acetonitrile is treated with tert-butyl 4-aminocyclohexanecarboxylate (0.026 mol). The reaction mixture is refluxed for about 3-4 hrs. Solvent is evaporated off and water is added and extraction is done with ethyl acetate. The organic layer is washed with brine, dried and concentrated under reduced pressure to give crude compound, which is purified by column chromatography.

1. temperatureThe reaction mixture is refluxed for about 3-4 hrs
2. customSolvent is evaporated off
3. additionwater is added
4. extractionextraction
5. washThe organic layer is washed with brine
6. customdried
7. concentrationconcentrated under reduced pressure
8. customto give crude compound, which
9. customis purified by column chromatography