反应详情

A mixture of 2-(bromomethyl)-5,8-dioxaspiro[3.4]octane (1.3 gm, 6.28 mmol) (step e), polyethylene glycol (PEG-600) (0.5 gm), 50% aqueous sodium hydroxide solution (5 ml) and benzene was refluxed for about 12 hours. The reaction mixture was cooled, diluted with water and extracted with diethyl ether. The organic layer was washed with brine, dried over sodium sulphate and concentrated under reduced pressure to get a crude product, which was purified by column chromatography.

1. temperaturewas refluxed for about 12 hours
2. temperatureThe reaction mixture was cooled
3. extractionextracted with diethyl ether
4. washThe organic layer was washed with brine
5. dry with materialdried over sodium sulphate
6. concentrationconcentrated under reduced pressure