反应详情

Ethyl 5-(bromomethyl)-3-[4-(cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-4,5-dihydroisoxazole-5-carboxylate (200 mg, 0.0004 mole) (example 19) was taken in tetrahydrofuran (15 ml). Sodium borohydride (31 mg, 0.0008 mole) was added portion wise. The reaction mixture was stirred overnight. It was quenched with saturated ammonium chloride solution. The organic solvent was removed, water was added and the mixture was extracted with ethyl acetate, washed with brine, dried over anhydrous sodium sulphate and concentrated in vacuo. The crude product obtained was purified by column chromatography.

1. customIt was quenched with saturated ammonium chloride solution
2. customThe organic solvent was removed
3. additionwater was added
4. extractionthe mixture was extracted with ethyl acetate
5. washwashed with brine
6. dry with materialdried over anhydrous sodium sulphate
7. concentrationconcentrated in vacuo