Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | HCID 86647604 | HCID 86647604 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86647606 | HCID 86647606 | — |
Reaction Steps
3-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-en-8-yl 4-methylbenzenesulfonate (0.00090 mole) (example 39) is taken in dimethylformamide. Sodium azide (0.0027 mole) is added. The reaction mixture is stirred at 60-70° C. overnight. It is cooled and water is added and extraction is done with ethyl acetate. The organic layer is washed with brine, dried and concentrated under reduced pressure to give crude compound, which is purified by column chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08420666B2 |
|---|
| Source dataset | uspto-grants-2013_04 |
|---|
| ORD ID | ord-200a446f100c47339217f82056d70804 |
|---|
| Source note | uspto-grants-2013_04 |
|---|
