Sodium Hydroxide → HCID 44611439, compound

Participants

Reaction Steps

To a solution of {(R)-4-[4-(2-chloro-phenoxy)-benzenesulfonylamino]-4,5,6,7-tetrahydro-indazol-1-yl}-acetic acid ethyl ester (example 1-1) (167 mg, 0.34 mmol) in tetrahydrofuran (3 mL) was added 1N sodium hydroxide (3 mL). The reaction mixture was stirred at room temperature for 2 hours, and then extracted with diethyl ether (10 mL). The organic layer was discarded. The aqueous layer was acidified with concentrated hydrochloric acid to pH 4 and stirred with diethyl ether (3 mL) and petroleum ether (9 mL) at room temperature for 2 hours. The resulting mixture was filtered through a glass funnel to afford {(R)-4-[4-(2-chloro-phenoxy)-benzenesulfonylamino]-4,5,6,7-tetrahydro-indazol-1-yl}-acetic acid (124 mg, 79%) as a white powder. 1H NMR (400 MHz, CD3OD) δ ppm 7.94 (d, 2 H), 7.60 (q, 1 H), 7.43 (m, 1 H), 7.26 (m, 2 H), 7.07 (d, 2 H), 6.70 (s, 1 H), 4.80 (s, 2 H), 4.37 (t, 1 H), 2.60-2.48 (m, 2 H), 1.94-1.75 (m, 4 H). MS cald. (calculated) for C21H20ClN3O5S 461, obsd. (observed) (ESI+) [(M+H)+] 462.

Provenance & Evidence