Tedizolid Impurity 32 → HCID 11177644, compound

HRID 1966931Notes

Reaction equation

HRID 1966931 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[N:2]1.[CH3:6][C:7]1[O:8][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][C:21]([N:24]4[CH2:28][C@H:27]([CH2:29]O)[O:26][C:25]4=[O:31])=[CH:20][C:19]=3[F:32])=[CH:14][N:13]=2)=[N:10][N:11]=1>>[CH3:6][C:7]1[O:8][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][C:21]([N:24]4[CH2:28][C@H:27]([CH2:29][N:1]5[CH:5]=[CH:4][N:3]=[N:2]5)[O:26][C:25]4=[O:31])=[CH:20][C:19]=3[F:32])=[CH:14][N:13]=2)=[N:10][N:11]=1

Participants

3

Reactant 2

HCID 11440117Tedizolid Impurity 32HCID 178418936HCID 178418936, compound

Product 1

HCID 11177644HCID 11177644, compound

Procedure

The same procedure as in Example 24 was conducted, except for adding 1,2,3-triazole and using the compound 16 as a starting material, to obtain the title compound.

Sources & evidence

ORD record
ord-0de3a75d6f794502a9751d8b3c6c5afe
Source dataset
uspto-grants-2013_04
Patent number
US08420676B2

Reaction notes

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