[2-(4-Bromophenyl)-1,3-thiazol-4-yl]methanol → HCID 86633018, compound

HRID 1966940Notes

Reaction equation

HRID 1966940 reaction equation
C[Sn](C)(C)[C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:13][C@H:12]([CH2:14][C:15](=[O:19])[C:16]([NH2:18])=[O:17])[O:11][CH2:10]2)=[CH:5][C:4]=1[F:20].[OH:23][CH2:24][C:25]1[N:26]=[C:27]([C:30]2[CH:35]=[CH:34][C:33](Br)=[CH:32][CH:31]=2)[S:28][CH:29]=1>>[OH:23][CH2:24][C:25]1[N:26]=[C:27]([C:30]2[CH:31]=[CH:32][C:33]([C:3]3[CH:8]=[CH:7][C:6]([N:9]4[CH2:13][C@H:12]([CH2:14][C:15](=[O:19])[C:16]([NH2:18])=[O:17])[O:11][CH2:10]4)=[CH:5][C:4]=3[F:20])=[CH:34][CH:35]=2)[S:28][CH:29]=1

Participants

3

Reactant 2

HCID 39369301[2-(4-Bromophenyl)-1,3-thiazol-4-yl]methanolHCID 86613473HCID 86613473, compound

Product 1

HCID 86633018HCID 86633018, compound

Procedure

With the exception of using (S)-3-(4-trimethylstannyl-3-fluorophenyl)-2-oxo-5-oxazolidinylmethyl acetamide as a starting material and 4-(4-hydroxymethylthiazol-2-yl)-bromobenzene, the same procedure as in Example 1 was conducted to prepare the title compound.

Sources & evidence

ORD record
ord-a5d6dfb04d924cc1810d2a6efb22c669
Source dataset
uspto-grants-2013_04
Patent number
US08420676B2

Reaction notes

Loading…