Hydrochloric Acid → HCID 66681061, compound

Participants

Reaction Conditions

Reaction Steps

1.8 g (22.2 mmol, 2 eq.) of potassium cyanate are added at 30° C. to a solution of 3.7 g (11.3 mmol, 1 eq.) of 1-(4-iodophenylamino)cyclohexanecarbonitrile in 30 ml of glacial acetic acid. The reaction medium is stirred at 60° C. overnight. 5 ml of hydrochloric acid and then 3 ml of water are added. The medium is heated at 90° C. for 1 hour and then at room temperature for 3 hours. Water is then poured into the reaction medium, and the precipitate formed is filtered off and then chromatographed on silica gel (50/50 heptane/ethyl acetate). 180 mg of 1-(4-iodophenyl)-1,3-diaza-spiro[4.5]decane-2,4-dione are obtained in the form of an orange-coloured solid.

Provenance & Evidence