1,2,3,4-Tetrahydroquinoxaline → [4-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-quinoxalin-1-yl)-methanone

HRID 1966970Notes

Reaction equation

HRID 1966970 reaction equation
[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4][CH2:3][CH2:2]1.[Cl:11][C:12]1[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][C:13]=1[O:14][C:15]1[CH:20]=[CH:19][N:18]=[CH:17][C:16]=1[C:21](N1C2C(=CC=CC=2)CCC1)=[O:22]>>[Cl:11][C:12]1[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][C:13]=1[O:14][C:15]1[CH:20]=[CH:19][N:18]=[CH:17][C:16]=1[C:21]([N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4][CH2:3][CH2:2]1)=[O:22]

Participants

3

Reactant 2

HCID 770281,2,3,4-TetrahydroquinoxalineHCID 53311781[4-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone

Product 1

HCID 53311864[4-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-quinoxalin-1-yl)-methanone

Procedure

The title compound was prepared in analogy to Example 1, from 1,2,3,4-tetrahydro-quinoxaline (commercially available; CAS RN 3476-89-9) and 4-(2,5-dichloro-phenoxy)-nicotinic acid (Example 1, intermediate). Light yellow foam (99%). MS (ESI): m/z=400.06 [M+H]+.

Sources & evidence

ORD record
ord-8c64bbbd5d2f49c7a8c633710fa540ba
Source dataset
uspto-grants-2013_04
Patent number
US08420647B2

Reaction notes

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