HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenamine, 3,5-bis(trifluoromethyl)- → N-(3,5-Bis-trifluoromethyl-phenyl)-4-(2,5-dichloro-phenoxy)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenamine, 3,5-bis(trifluoromethyl)- | HCID 9480 | — |
| Reactant | [4-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone | HCID 53311781 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | N-(3,5-Bis-trifluoromethyl-phenyl)-4-(2,5-dichloro-phenoxy)-nicotinamide | HCID 86655953 | — |
Reaction Steps
The title compound was prepared in analogy to Example 1, from 4-(2,5-dichloro-phenoxy)-nicotinic acid (Example 1, intermediate) and 3,5-bis(trifluoromethyl)aniline (commercially available; CAS RN 328-74-5) and using a gradient of n-heptane:ethyl acetate (100:0 to 40:60) for the chromatographic purification. Light yellow foam (44%). MS (ESI): m/z=495.010 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420647B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-b0358ce4bfc84a4bb6b0aadbbd560d15 |
| Source note | uspto-grants-2013_04 |