HuagongsheHuagongshe Chemistry Print Report · For research reference only
[4-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone → (2-{[4-(2,5-Dichloro-phenoxy)-pyridine-3-carbonyl]-amino}-4,5-difluoro-phenyl)-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [4-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone | HCID 53311781 | — |
| Reactant | tert-Butyl (2-amino-4,5-difluorophenyl)carbamate | HCID 66619231 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | (2-{[4-(2,5-Dichloro-phenoxy)-pyridine-3-carbonyl]-amino}-4,5-difluoro-phenyl)-carbamic acid tert-butyl ester | HCID 67321135 | — |
Reaction Steps
The title compound was prepared in analogy to Example 1, from 4-(2,5-dichloro-phenoxy)-nicotinic acid (Example 1, intermediate) and (2-amino-4,5-difluoro-phenyl)-carbamic acid tert-butyl ester (WO2008000643A1) and using a gradient of n-heptane:ethyl acetate (100:0 to 40:60) for the chromatographic purification. Light yellow solid (73%). MS (ESI): m/z=510.080 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420647B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-60225aba32974d20ba59a0b142fcb761 |
| Source note | uspto-grants-2013_04 |