HuagongsheHuagongshe Chemistry Print Report · For research reference only
N2,N2-Dimethyl-2,3-pyridinediamine → 4-(2,5-dichloro-phenoxy)-N-(2-dimethylamino-pyridin-3-yl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N2,N2-Dimethyl-2,3-pyridinediamine | HCID 15656134 | — |
| Reactant | [4-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone | HCID 53311781 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | 4-(2,5-dichloro-phenoxy)-N-(2-dimethylamino-pyridin-3-yl)-nicotinamide | HCID 67320131 | — |
Reaction Steps
The title compound was prepared in analogy to Example 1, from 4-(2,5-dichloro-phenoxy)-nicotinic acid (Example 1, intermediate), 3-amino-2-(dimethylamino)pyridine (commercially available, CAS RN 5028-25-1) and using a gradient of n-heptane:ethyl acetate (100:0 to 0:100) for the chromatographic purification. Light yellow solid (73%). MS (ESI): m/z=403.072 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420647B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-c8f113e6d0f9487c8c30b0ecb7771a97 |
| Source note | uspto-grants-2013_04 |