HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Lithium 2-chloro-4-(2,5-dichloro-phenoxy)-6-methyl-nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | 2-Chloro-4-(2,5-dichloro-phenoxy)-6-methyl-nicotinic acid ethyl ester | HCID 86686936 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Lithium 2-chloro-4-(2,5-dichloro-phenoxy)-6-methyl-nicotinate | HCID 86655954 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
To a solution of 130 mg (0.36 mmol) 2-chloro-4-(2,5-dichloro-phenoxy)-6-methyl-nicotinic acid ethyl ester in 2 mL dioxane was added 2 mL water and 23 mg (0.541 mmol) lithium hydroxide monohydrate. The reaction mixture was stirred at 100° C. for 4 hours. The reaction mixture was allowed to cool down to room temperature and was concentrated under high vacuum. The so-obtained light yellow solid was pure enough for the next step without further purification. MS (ESI): 331.965 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420647B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-91120971977b4f2bb032300b2728cb95 |
| Source note | uspto-grants-2013_04 |