HuagongsheHuagongshe Chemistry Print Report · For research reference only
(-)-Carnitine → [4-(2,5-Dichloro-phenoxy)-pyrimidin-5-yl]-(4-methyl-3,4-dihydro-2H-quinoxalin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (-)-Carnitine | HCID 10917 | — |
| Reactant | 1-Methyl-1,2,3,4-tetrahydroquinoxaline | HCID 215850 | — |
| Reactant | 4-(2,5-Dichloro-phenoxy)-pyrimidine-5-carboxylic acid | HCID 67320261 | — |
| Product | [4-(2,5-Dichloro-phenoxy)-pyrimidin-5-yl]-(4-methyl-3,4-dihydro-2H-quinoxalin-1-yl)-methanone | HCID 53311701 | 8% |
Reaction Steps
The title compound was prepared in analogy to Example 77, from 4-(2,5-dichloro-phenoxy)-pyrimidine-5-carboxylic acid and 1-methyl-1,2,3,4-tetrahydroquinoxaline (commercially available, Metina, catalog number M-636). The compound was purified by preparative HPLC (Phenomenex Gemini column) using a gradient of acetonitrile:water (10:90 to 98:2) to give 6.5 mg (8%) of the desired compound. MS (ESI): m/z=415.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420647B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-cedbe2877d9c4bcbb9c00fe4fc0a1e07 |
| Source note | uspto-grants-2013_04 |