Methanol → Methyl (benzylthio)acetate

HRID 1967080Notes

Reaction equation

HRID 1967080 reaction equation
[CH2:1]([S:8][CH2:9][C:10]([OH:12])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:13]O>>[CH2:1]([S:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 887MethanolHCID 668972-((Phenylmethyl)thio)acetic acid

Product 1

HCID 562502Methyl (benzylthio)acetate

Procedure

S-benzylthioglycolic acid (12.0 g) was dissolved in 250 mL of methanol and sparged with hydrogen chloride gas at room temperature for 20 minutes. The solvent was then removed under vacuum. Methyl S-benzylthioglycolate obtained was used in the next step without further purification.

Workup

  1. customsparged with hydrogen chloride gas at room temperature for 20 minutes
  2. customThe solvent was then removed under vacuum

Sources & evidence

ORD record
ord-5836acfefac349a892f477a84aa0b557
Source dataset
uspto-grants-2013_04
Patent number
US08420698B2

Reaction notes

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