HuagongsheHuagongshe Chemistry Print Report · For research reference only
o-Fluorobenzaldehyde → HCID 136201128, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | o-Fluorobenzaldehyde | HCID 67970 | — |
| Reactant | 1H-Imidazole-1-propanamine | HCID 78736 | — |
| Reactant | 3-(2-isocyanoethyl)-1H-indole | HCID 2769499 | — |
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Reactant | HCID 178418250 | HCID 178418250 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 136201128 | HCID 136201128 | — |
Reaction Steps
3-Imidazol-1-yl-propylamine (1 mmol) and 2-Fluorobenzaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours 2 ml of a solution of KOCN (KSCN) (2 mmol) and Pyridinehydrochloride (2 mmol) in MeOH is added was added. Finally 3-(2-Isocyano-ethyl)-1H-indole (1 mmol) is added. The reaction was stirred at room temperature for 48 h. After evaporation of the solvent the residue was purified with chromatographic methods.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420684B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-51b2ec7a14c5426b98075ad0358dc18b |
| Source note | uspto-grants-2013_04 |