HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-2,6-difluorobenzaldehyde → HCID 178517957, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-2,6-difluorobenzaldehyde | HCID 736338 | — |
| Reactant | 1,2,3,4-Tetrahydro-1-isocyanonaphthalene | HCID 2759469 | — |
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Reactant | HCID 178418250 | HCID 178418250 | — |
| Reactant | HCID 178507353 | HCID 178507353 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178517957 | HCID 178517957 | — |
Reaction Steps
1H-Benzoimidazol-5-ylamine (1 mmol) and 3-Chloro-2,6-difluorobenzaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours 2 ml of a solution of KOCN (KSCN) (2 mmol) and Pyridinehydrochloride (2 mmol) in MeOH is added was added. Finally 1-Isocyano-1,2,3,4-tetrahydro-naphthalene (1 mmol) is added. The reaction was stirred at room temperature for 48 h. After evaporation of the solvent the residue was purified with chromatographic methods.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420684B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-f10f4d3cd89d4ed59e64d655e59fada0 |
| Source note | uspto-grants-2013_04 |