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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1967136Generated: October 29, 2026

Methanol → HCID 178518164, compound

https://huagongshe.com/reaction/1967136

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
Reactant4-BromobenzaldehydeHCID 70741—
ReactantPyridinium chlorideHCID 10176127—
ReactantHCID 178418250HCID 178418250—
ReactantHCID 178507353HCID 178507353—
ProductHCID 178518164HCID 178518164—

Reaction Steps

1H-Benzoimidazol-5-ylamine (1 mmol) and 4-Bromobenzaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours 2 ml of a solution of KOCN (KSCN) (2 mmol) and Pyridinehydrochloride (2 mmol) in MeOH is added was added. Finally 3-(S)-1-Isocyano-indan (1 mmol) is added. The reaction was stirred at room temperature for 48 h. After evaporation of the solvent the residue was purified with chromatographic methods.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08420684B2
Source datasetuspto-grants-2013_04
ORD IDord-aecc5f569c0a4f3eaad3840122d644b6
Source noteuspto-grants-2013_04