HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formic Acid → 5-Bromo-2-nitrothiophene-3-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | 5-Bromo-3-(dichloromethyl)-2-nitrothiophene | HCID 59525607 | — |
| Catalyst | Zincchloride | HCID 3007855 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Bromo-2-nitrothiophene-3-carbaldehyde | HCID 53402947 | — |
Reaction Steps
5-Bromo-3-(dichloromethyl)-2-nitrothiophene (60.5 g, 208 mmol) and zinc chloride (113 g, 832 mmol) were stirred in refluxing formic acid (800 mL) overnight. After cooling to ambient temperature, water was added and the mixture was extracted with EtOAc (4×). The combined organic extracts were washed with brine, dried over MgSO4, filtered, and concentrated in vacuo to give the title compound as an orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420695B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-f68080b21a334d46956aa02fd6a2cd4c |
| Source note | uspto-grants-2013_04 |