HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Bromobenzoyl)morpholine → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}thiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Bromobenzoyl)morpholine | HCID 532148 | — |
| Reactant | 2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide | HCID 59525619 | — |
| Product | 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}thiophene-3-carboxamide | HCID 44608313 | — |
Reaction Steps
5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}thiophene-3-carboxamide was prepared according to the general procedure in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.11 g, 0.352 mmol) and 4-(4-bromobenzoyl)morpholine (0.095 g, 0.352 mmol) as the starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420695B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-89b55f26aa10424c91c91f5166f228e6 |
| Source note | uspto-grants-2013_04 |