Cefadroxil monohydrate → Cefadroxil

Participants

Reaction Steps

8.4 ml of formic acid (85% v/v) were added to the cefadroxil monohydrate solution obtained in step (a) in such a way that the pH decreased to 6.0 in 30 minutes. The obtained cefadroxil monohydrate suspension was stirred for 30 min. The suspension was filtered and the cake was washed with 50 ml of water followed by 34 ml acetone. After drying, 72.8 g of cefadroxil was obtained (84.7% (w/w) yield). The CIE b value of the cefadroxil monohydrate crystals was 4.52.

Provenance & Evidence