HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Dibenzo[b,f][1,4]thiazepin-11-ylamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Dibenzo(b,f)(1,4)thiazepin-11-amine | HCID 374037 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | TBME isopropanol | HCID 86616950 | — |
| Product | Dibenzo[b,f][1,4]thiazepin-11-ylamine hydrochloride | HCID 44158775 | 91% |
Reaction Steps
A solution of gaseous HCl in i-PrOH (5.7 g, 31 wt-%) was added dropwise under stirring to a solution of dibenzo[b,f][1,4]thiazepin-11-ylamine (10.6 g) dissolved in a isopropanol/tert-butyl methyl ether (TBME) mixture (150 ml/120 ml). Stirring was continued for 1 h and the formed precipitate was filtered off, washed with tert-butyl methyl ether (TBME) and dried on air to obtain the desired compound as a colorless solid (11.2 g, 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420807B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-79876ac24f6346eb98e31d846d8fd968 |
| Source note | uspto-grants-2013_04 |