HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitric Acid → 1-(5-(Benzyloxy)-2-hydroxy-3-nitrophenyl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | 1-[5-(Benzyloxy)-2-hydroxyphenyl]ethan-1-one | HCID 12870928 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1-(5-(Benzyloxy)-2-hydroxy-3-nitrophenyl)ethanone | HCID 21072823 | — |
Reaction Steps
10.00 kg (41.27 mol) 1-[2-hydroxy-5-(phenylmethoxy)-phenyl]-ethanone 5a are dissolved in 50 l acetic acid. 4.40 kg (45.40 mol) nitric acid 65% are metered into this solution at 15 to 20° C. The feed vessel is rinsed with 4 l acetic acid. The reaction mixture is stirred for 1 hour. After inoculation 50 l water are added. The suspension obtained is stirred for 1 hour at 10° C. to complete the crystallisation. The product is centrifuged and dried at 50° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420809B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-8975e70275e24129a376e4cca65a41f4 |
| Source note | uspto-grants-2013_04 |