Phenylacetylene → HCID 25221948, compound

HRID 1967195Notes

Reaction equation

HRID 1967195 reaction equation
[CH3:1][N:2]1[C:6](OS(C2C=CC(C)=CC=2)(=O)=O)=[CH:5][C:4]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[N:3]1.[C:24]1([C:30]#[CH:31])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CCCCCCC.C(Cl)Cl>[CH3:1][N:2]1[C:6]([C:31]#[C:30][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[CH:5][C:4]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)=[N:3]1

Participants

4

Reactant 2

HCID 10821PhenylacetyleneHCID 866466171-methyl-3-phenyl-1H-pyrazol-5-yl 4-methylbenzene-1-sulfonate

Product 1

HCID 25221948HCID 25221948, compound

Reagents, catalysts & solvents 1

HCID 21907733Dichloromethane heptaneSolvent

Procedure

This product was prepared from toluene-4-sulfonic acid 2-methyl-5-phenyl-2H-pyrazol-3-yl ester and phenylacetylene. Chromatography eluent: heptane/DCM 1:1; yield (64 mg, 50%); 1H NMR δ (CDCl3): 7.78 (d, J=8.22 Hz, 2H), 7.65-7.57 (m 5H), 7.43-7.34 (m, 3H), 6.63 (s, 1H), 3.98 (s, 3H); LCMS m/z: 258.

Workup

  1. customyield (64 mg, 50%)

Sources & evidence

ORD record
ord-be829934b60f4c9dab925793107dc988
Source dataset
uspto-grants-2013_04
Patent number
US08420812B2

Reaction notes

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