5-Phenyl-1-pentyne → HCID 25221950, compound

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Reaction Steps

This product was prepared from 3-(toluene-4-sulfonyloxy)-thiophene-2-carboxylic acid methyl ester and pent-4-ynyl-benzene following the general procedure for the Sonogashira cross-coupling reaction described above. Chromatography eluent: heptane/DCM 4:6; yield (114 mg, 80%); 1H NMR δ (CDCl3): 7.33 (d, J=4.93 Hz, 1H), 7.16-7.09 (m, 5H), 7.01 (d, J=4.95 Hz, 1H), 3.81 (s, 3H), 2.77 (t, J=7.11 Hz, 2H), 2.42 (t, J=7.16 Hz, 2H), 1.94 (p, J=7.22 Hz, 2H); LCMS m/z: 284.

Provenance & Evidence