1-Heptyne → HCID 25221951, compound

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Reaction Steps

This product was prepared from 3-(toluene-4-sulfonyloxy)-thiophene-2-carboxylic acid methyl ester and 1-heptyne following the general procedure for the Sonogashira cross-coupling reaction described above. Chromatography eluent: heptane/DCM 1:1; yield (71 mg, 60%); 1H NMR δ (CDCl3): 7.32 (d, J=5.03 Hz, 1H), 7.01 (d, J=5.10 Hz, 1H), 3.81 (s, 3H), 2.42 (t, J=7.25 Hz, 2H), 1.57 (p, J=7.19 Hz, 2H), 1.45-1.26 (m, 4H), 0.87 (t, J=7.2 Hz, 3H); LCMS m/z: 236.

Provenance & Evidence