5-Phenyl-1-pentyne → HCID 25222066, compound

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Reaction Steps

This product was prepared from toluene-4-sulfonic acid 1-benzyl-1H-indazol-3-yl ester and pent-4-ynyl-benzene following the general procedure for the Sonogashira cross-coupling reaction described above. Chromatography eluent: heptane/DCM 1:1; yield (87.5 mg, 50%); δH (CDCl3): 7.92 (d, J=8.11 Hz, 1H), 7.4-7.19 (m, 8H), 7.15-7.08 (m, 5H), 5.5 (s, 2H), 2.76 (t, J=7.16 Hz, 2H), 2.4 (t, J=7.15 Hz, 2H), 1.91 (p, J=7.21 Hz, 2H); LCMS m/z: 350.

Provenance & Evidence