1-Heptyne → HCID 68498012, compound

Participants

Reaction Steps

This product was prepared from toluene-4-sulfonic acid 1-p-tolyl-1H-pyrazolo[3,4-b]pyridin-3-yl ester and 1-heptyne following the general procedure for the Sonogashira cross-coupling reaction described above. Chromatography eluent: heptane/iPr2ether 1:1; yield (110 mg, 73%); 1H NMR δ (CDCl3): 8.63 (m, 1H), 8.19 (m, 1H), 8.10 (d, J=8.55 Hz, 2H), 7.32 (d, J=8.46 Hz, 2H), 7.20-7.27 (m, 1H), 2.53 (t, J=7.23 Hz, 2H), 2.39 (s, 3H), 1.71 (p, J=7.19 Hz, 2H), 1.57-1.46 (m, 2H), 1.45-1.33 (m, 2H), 0.94 (t, J=7.20 Hz, 3H); LCMS m/z: 303.

Provenance & Evidence