HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethynyl-4-methoxybenzene → HCID 25222180, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethynyl-4-methoxybenzene | HCID 251020 | — |
| Reactant | Toluene-4-sulfonic acid 6-methyl-pyrimidin-4-yl ester | HCID 86646621 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | HCID 25222180 | HCID 25222180 | — |
Reaction Steps
This product was prepared from toluene-4-sulfonic acid 6-methyl-pyrimidin-4-yl ester and 1-ethynyl-4-methoxy-benzene following the general procedure for the Sonogashira cross-coupling reaction described above. Chromatography eluent: heptane/EtOAc 8:2; yield (52 mg, 46%); 1H NMR δ (CDCl3): 8.99 (s, 1H), 7.32 (d, J=8.60 Hz, 2H), 7.22 (s, 1H), 7.17 (d, J=8.43 Hz, 2H), 3.83 (s, 3H), 2.51 (s, 3H); LCMS m/z: 224.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420812B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-23efff816ff9466183accbaa97436cb0 |
| Source note | uspto-grants-2013_04 |