HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 59556964, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Reactant | HCID 59556992 | HCID 59556992 | — |
| Reactant | 4-Bromo-2-chloro-3-methylbenzonitrile | HCID 67104957 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Product | HCID 59556964 | HCID 59556964 | — |
Reaction Steps
Using (4S,5S)-4-(tert-butyldimethylsilyloxy)-5-methylpyrrolidin-2-one (495 mg), 4-bromo-2-chloro-3-methylbenzonitrile (500 mg), cesium carbonate (1.05 g), tris(dibenzylideneacetone)dipalladium(0) (99 mg) and 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (124 mg), and in the same manner as in Reference Example 3, the title compound was obtained as a colorless solid (yield: 505 mg, 74%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420694B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-5645a79182424c30ac1dae90cbecfce3 |
| Source note | uspto-grants-2013_04 |