HCID 57577513, compound → HCID 59557008, compound

HRID 1967249Notes

Reaction equation

HRID 1967249 reaction equation
C(OC([NH:11][CH:12]([CH:23]([CH3:25])[CH3:24])[C:13](=[O:22])[C:14]([CH3:21])([CH3:20])[C:15](OCC)=[O:16])=O)C1C=CC=CC=1>CO.[C].[Pd]>[CH:23]([CH:12]1[NH:11][C:15](=[O:16])[C:14]([CH3:21])([CH3:20])[C:13]1=[O:22])([CH3:25])[CH3:24]

Participants

4

Reactant 1

HCID 57577513HCID 57577513, compound

Product 1

HCID 59557008HCID 59557008, compoundYield 76%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

To a solution of ethyl 4-{[(benzyloxy)carbonyl]amino}-2,2,5-trimethyl-3-oxohexanoate (7.2 g) in methanol (80 mL) was added 10% palladium carbon (containing 50% water, 3.0 g), and the mixture was stirred under a hydrogen atmosphere overnight. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The obtained solid was washed with hexane to give the title compound as a colorless solid (yield: 2.64 g, 76%).

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. washThe obtained solid was washed with hexane

Sources & evidence

ORD record
ord-68e85d97889e492e928d239d5dd7c5da
Source dataset
uspto-grants-2013_04
Patent number
US08420694B2

Reaction notes

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