HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 67104985, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Reactant | 4-Bromo-2-chlorobenzonitrile | HCID 7010420 | — |
| Reactant | HCID 67105767 | HCID 67105767 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Product | HCID 67104985 | HCID 67104985 | — |
Reaction Steps
Using (6RS,7RS)-7-(tert-butyldimethylsilyloxy)-6-methyl-5-azaspiro[2.4]heptan-4-one (162 mg), 4-bromo-2-chlorobenzonitrile (157 mg), cesium carbonate (310 mg), tris(dibenzylideneacetone)dipalladium(0) (30 mg) and 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (75 mg), and in the same manner as in Reference Example 3, the title compound was obtained as a colorless solid (yield: 140 mg, 56%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420694B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-79f5334b0e434f2097f0a65b87a67689 |
| Source note | uspto-grants-2013_04 |