HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 59556981, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Reactant | 4-Iodo-2-(trifluoromethyl)benzonitrile | HCID 16218337 | — |
| Reactant | HCID 59556944 | HCID 59556944 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Product | HCID 59556981 | HCID 59556981 | — |
Reaction Steps
Using (4R,5S)-4-(tert-butyldimethylsilyloxy)-3,3,5-trimethylpyrrolidin-2-one (266.6 mg), 4-iodo-2-(trifluoromethyl)benzonitrile (340 mg), cesium carbonate (505 mg), tris(dibenzylideneacetone)dipalladium(0) (47 mg) and 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (120 mg), and in the same manner as in Reference Example 3, the title compound was obtained as a colorless oil (yield: 391.7 mg, yield: 89%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420694B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-846999e1556544909ad260fabf520ae9 |
| Source note | uspto-grants-2013_04 |