HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(5-Ethyl-3,3-dimethyl-2,4-dioxopyrrolidin-1-yl)-2-methoxybenzonitrile → Rac-4-[(4r,5r)-5-ethyl-4-hydroxy-3,3-dimethyl-2-oxopyrrolidin-1-yl]-2-methoxybenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(5-Ethyl-3,3-dimethyl-2,4-dioxopyrrolidin-1-yl)-2-methoxybenzonitrile | HCID 59556897 | — |
| Reactant | L-SELECTRIDE tetrahydrofuran | HCID 131725857 | — |
| Product | Rac-4-[(4r,5r)-5-ethyl-4-hydroxy-3,3-dimethyl-2-oxopyrrolidin-1-yl]-2-methoxybenzonitrile | HCID 67105799 | — |
Reaction Steps
Using 4-(5-ethyl-3,3-dimethyl-2,4-dioxopyrrolidin-1-yl)-2-methoxybenzonitrile (120 mg) and lithium tri(sec-butyl)borohydride-THF solution (0.629 mL, 1 mol/L), and in the same manner as in Example 5, the title compound was obtained as a colorless solid (yield: 93 mg, 77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420694B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-23c2188a34ff4d0995fc5a142cd83fa8 |
| Source note | uspto-grants-2013_04 |