Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloro-4-(5-ethyl-3,3-dimethyl-2,4-dioxopyrrolidin-1-yl)benzonitrile → Rac-2-chloro-4-[(2r,3r)-2-ethyl-3-hydroxy-3,4,4-trimethyl-5-oxopyrrolidin-1-yl]benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloro-4-(5-ethyl-3,3-dimethyl-2,4-dioxopyrrolidin-1-yl)benzonitrile | HCID 59557016 | — |
| 반응물 | HCID 178420675 | HCID 178420675 | — |
| 생성물 | Rac-2-chloro-4-[(2r,3r)-2-ethyl-3-hydroxy-3,4,4-trimethyl-5-oxopyrrolidin-1-yl]benzonitrile | HCID 67105654 | — |
반응 단계
Using 2-chloro-4-(5-ethyl-3,3-dimethyl-2,4-dioxopyrrolidin-1-yl)benzonitrile (48 mg) and methylmagnesium bromide-THF solution (1.65 mL, 1.0 mol/L), and in the same manner as in Example 2, the title compound was obtained as a colorless solid (yield: 27 mg, 53%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08420694B2 |
| 출처 데이터셋 | uspto-grants-2013_04 |
| ORD ID | ord-732f463821864809857820ccac08f2bc |
| 출처 메모 | uspto-grants-2013_04 |