Ammonium Chloride → HCID 66872348, compound

Participants

Reaction Steps

The compound (50 mg) obtained in Example 56 was dissolved in DMF (1.0 mL), then N,N-diisopropylethylamine (0.030 mL), ammonium chloride (8 mg), 1-hydroxybenzotriazole hydrate (22 mg) and N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (27 mg) were added thereto in that order, and stirred at room temperature for 3 days. Water was added to the reaction liquid, and extracted four times with ethyl acetate. The organic layers were combined, washed with saturated brine, and dried with sodium sulfate. The drying agent was removed through filtration, and the solvent was evaporated off under reduced pressure. The residue was purified through silica gel column chromatography (methanol/chloroform=from 0% to 20%, gradient) to give the entitled compound (37 mg, 74%) as a colorless solid.

Provenance & Evidence