Pyridine → HCID 2303847, compound

Participants

Reaction Steps

4-Fluoroaniline (41 mg), pyridine (0.06 mL) and N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (107 mg) were added in that order to a DMF (2.0 mL) solution of 3-(piperidin-1-ylsulfonyl)benzoic acid (100 mg), and stirred at room temperature for 14 hours. Ethyl acetate was added to the reaction liquid, washed twice with 2 M hydrochloric acid, and dried with sodium sulfate. The drying agent was removed through filtration, and the solvent was evaporated off. The residue was purified through silica gel column chromatography (ethyl acetate/hexane=from 5% to 50%, gradient) to give the entitled compound (87 mg, 65%) as a white crystal.

Provenance & Evidence