HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → N-benzyl-3-piperidin-1-ylsulfonylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-(Piperidine-1-sulfonyl)benzoic acid | HCID 767889 | — |
| Reactant | 1H-Imidazolium, 2-chloro-4,5-dihydro-1,3-dimethyl-, chloride | HCID 10986715 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-benzyl-3-piperidin-1-ylsulfonylbenzamide | HCID 1076673 | 65.1% |
Reaction Steps
Benzylamine (12 mg), triethylamine (0.047 mL) and 25% dichloromethane solution of 2-chloro-1,3-dimethylimidazolinium chloride (0.11 mL) were added in that order to a chloroform (0.30 mL) solution of 3-(piperidin-1-ylsulfonyl)benzoic acid (30 mg), and stirred at room temperature for 1 hour. The reaction liquid was concentrated and purified through reversed-phase HPLC (0.1% TFA acetonitrile/H2O=from 10% to 95%, gradient) to give the entitled compound (26 mg, 65%) as a white crystal.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420823B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-d71fb545cf914fc5a1a711f2adb6ac1f |
| Source note | uspto-grants-2013_04 |