反应详情

Sodium borohydride (8.8 mg) was added to an ethanol (2.0 mL) solution of the compound (30.0 mg) obtained in Example 92, and stirred overnight at room temperature. Aqueous saturated ammonium chloride solution was added to the reaction liquid, extracted three times with ethyl acetate, and dried with sodium sulfate. The drying agent was removed through filtration, and the solvent was evaporated off under reduced pressure. The residue was purified through silica gel column chromatography (ethyl acetate/hexane=from 0% to 80%, gradient) to give the entitled compound (29.7 mg, 98%) as a white solid.

1. extractionextracted three times with ethyl acetate
2. dry with materialdried with sodium sulfate
3. customThe drying agent was removed through filtration
4. customthe solvent was evaporated off under reduced pressure
5. customThe residue was purified through silica gel column chromatography (ethyl acetate/hexane=from 0% to 80%, gradient)