反应详情

10% palladium-carbon (3.0 mg) as a catalyst was added to an ethanol (2.0 mL) solution of the compound (9.0 mg) obtained in Example 107, and stirred overnight in a hydrogen atmosphere at room temperature. The catalyst was removed through filtration, the solvent was evaporated off under reduced pressure, and the resulting residue was purified through silica gel column chromatography (methanol/chloroform=from 0% to 20%, gradient) to give the entitled compound (8.5 mg, 94%) as a colorless oily substance.

1. customThe catalyst was removed through filtration
2. customthe solvent was evaporated off under reduced pressure
3. customthe resulting residue was purified through silica gel column chromatography (methanol/chloroform=from 0% to 20%, gradient)