Toluene → HCID 86649793, compound

Participants

Reaction Steps

3-Methoxypyridine-2-amine (780 mg) was added to a toluene (50 mL) solution of 3-(chlorosulfonyl)benzoyl chloride (3.00 g), and stirred overnight at room temperature. Ethyl acetate was added to the reaction liquid, then washed twice with water and once with saturated brine, and dried with sodium sulfate. The drying agent was removed through filtration, and the solvent was evaporated off under reduced pressure. The residue was purified through silica gel column chromatography (ethyl acetate/hexane=form 0% to 80%, gradient) to give the entitled compound (608 mg, 18%) as a white solid.

Provenance & Evidence