Chloromethyl Methyl Ether → HCID 86649795, compound

Participants

Reaction Steps

With cooling with ice, chloromethyl methyl ether (1.04 mL) and potassium carbonate (3.16 g) were added to an acetone (30 mL) solution of 2-bromo-6-nitropyridin-3-ol (1.0 g), and stirred overnight at room temperature. The reaction liquid was concentrated under reduced pressure, ethyl acetate was added to the residue and washed with water and saturated brine. The organic layer was dried with sodium sulfate, then filtered and concentrated under reduced pressure. The residue was purified through silica gel column chromatography (ethyl acetate/hexane=from 0% to 50%, gradient) to give the intended product (1.16 g, 97%) as a brown solid.

Provenance & Evidence