Hydrochloric Acid → HCID 58138258, compound

Participants

Reaction Steps

Heat a solution of N-[1-(2-cyclopropyl-pyrimidin-4-yl)-1-methyl-ethyl]-acetamide (4.5 g, 20.5 mmol) and aqueous 5N HCl (125 mL) to 100° C. for 18 hours. Cool the mixture to room temperature. Extract the reaction with diethyl ether (2×) then make the aqueous layer alkaline with aqueous 5N NaOH. Extract the aqueous layer with diethyl ether (3×), dry the combined organic layers over sodium sulfate, filter, and concentrate under reduced pressure to give 1-(2-cyclopropyl-pyrimidin-4-yl)-1-methyl-ethylamine (1.3 g, 36%) as a dark yellow oil. 1H NMR (400 MHz, CDCl3): δ 8.45 (d, J=5.6 Hz, 1H), 7.12 (d, J=5.6 Hz, 1H), 2.30 (m, 1H), 1.76 (br s, 2H), 1.41 (s, 6H), 1.09 (m, 2H), 1.02 (m, 2H).

Provenance & Evidence